OR8G2

Protein-coding gene in the species Homo sapiens
OR8G2P
Identifiers
AliasesOR8G2P, HSTPCR120, OR8G4, ORL206, ORL486, TPCR120, OR8G2, olfactory receptor family 8 subfamily G member 2, olfactory receptor family 8 subfamily G member 2 pseudogene
External IDsMGI: 3030063; HomoloGene: 115513; GeneCards: OR8G2P; OMA:OR8G2P - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR8G2P
Genomic location for OR8G2P
Band11q24.2Start124,224,732 bp[1]
End124,225,666 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for OR8G2P
Genomic location for OR8G2P
Band9|9 A5.1Start39,818,632 bp[2]
End39,824,028 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
    n/a
    n/a
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • olfactory receptor activity
  • odorant binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • signal transduction
  • response to stimulus
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26492

258606

Ensembl

ENSG00000181214

ENSMUSG00000095390

UniProt

Q6IF36

Q8VFN5

RefSeq (mRNA)

NM_001291438

NM_146613

RefSeq (protein)

NP_001278367

NP_666824

Location (UCSC)Chr 11: 124.22 – 124.23 MbChr 9: 39.82 – 39.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 8G2 is a protein that in humans is encoded by the OR8G2 gene.[5][6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181214 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000095390 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M (Apr 1997). "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species". Genomics. 39 (3): 239–46. doi:10.1006/geno.1996.4490. PMID 9119360.
  6. ^ a b "Entrez Gene: OR8G2 olfactory receptor, family 8, subfamily G, member 2".

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
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