Protein-coding gene in the species Homo sapiens
| OR51B4 |
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| Identifiers |
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| Aliases | OR51B4, HOR5'Beta1, olfactory receptor family 51 subfamily B member 4 |
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| External IDs | MGI: 1341906; HomoloGene: 88376; GeneCards: OR51B4; OMA:OR51B4 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 11 (human)[1] |
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| | Band | 11p15.4 | Start | 5,301,014 bp[1] |
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| End | 5,301,946 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 7 (mouse)[2] |
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| | Band | 7|7 E3 | Start | 103,528,650 bp[2] |
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| End | 103,535,459 bp[2] |
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|
| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - gonad
- right ovary
- left ovary
- right adrenal gland
- uterine tube
- myometrium
- right adrenal cortex
- body of uterus
- ectocervix
- muscle of thigh
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| | | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - G protein-coupled receptor activity
- olfactory receptor activity
- signal transducer activity
| | Cellular component | - integral component of membrane
- plasma membrane
- membrane
| | Biological process | - sensory perception of smell
- signal transduction
- response to stimulus
- detection of chemical stimulus involved in sensory perception of smell
- G protein-coupled receptor signaling pathway
| | Sources:Amigo / QuickGO |
|
| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 11: 5.3 – 5.3 Mb | Chr 7: 103.53 – 103.54 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Olfactory receptor 51B4 is a protein that in humans is encoded by the OR51B4 gene.[5]
Function
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000183251 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058200 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR51B4 olfactory receptor, family 51, subfamily B, member 4".
Further reading
- Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M, von Doorninck JH (April 1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 5129–34. Bibcode:1999PNAS...96.5129B. doi:10.1073/pnas.96.9.5129. PMC 21828. PMID 10220430.
- Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R (December 2000). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14560–5. Bibcode:2000PNAS...9714560B. doi:10.1073/pnas.97.26.14560. PMC 18958. PMID 11121057.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
