OR2S2

Protein-coding gene in the species Homo sapiens
OR2S2
Identifiers
AliasesOR2S2, OR37A, OST715, olfactory receptor family 2 subfamily S member 2 (gene/pseudogene), olfactory receptor family 2 subfamily S member 2
External IDsMGI: 1352681; HomoloGene: 84331; GeneCards: OR2S2; OMA:OR2S2 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for OR2S2
Genomic location for OR2S2
Band9p13.3Start35,957,108 bp[1]
End35,958,154 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for OR2S2
Genomic location for OR2S2
Band4|4 B1Start43,851,565 bp[2]
End43,857,595 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of colon

  • mucosa of transverse colon

  • superior frontal gyrus

  • prefrontal cortex

  • left ventricle
Top expressed in
  • embryo

  • respiratory epithelium

  • nose

  • nasal epithelium

  • olfactory system

  • olfactory epithelium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • signal transducer activity
  • olfactory receptor activity
  • G protein-coupled receptor activity
Cellular component
  • plasma membrane
  • membrane
  • integral component of membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56656

29845

Ensembl

ENSG00000278889

ENSMUSG00000071000

UniProt

Q9NQN1

Q9QZ22

RefSeq (mRNA)

NM_019897

NM_019473

RefSeq (protein)

NP_063950

NP_062346

Location (UCSC)Chr 9: 35.96 – 35.96 MbChr 4: 43.85 – 43.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2S2 is a protein that in humans is encoded by the OR2S2 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000278889 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071000 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR2S2 olfactory receptor, family 2, subfamily S, member 2".

Further reading

  • Strotmann J, Hoppe R, Conzelmann S, et al. (1999). "Small subfamily of olfactory receptor genes: structural features, expression pattern and genomic organization". Gene. 236 (2): 281–91. doi:10.1016/S0378-1119(99)00275-9. PMID 10452948.
  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.145.6233. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hoppe R, Breer H, Strotmann J (2004). "Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human". Genomics. 82 (3): 355–64. doi:10.1016/S0888-7543(03)00116-2. PMID 12906860.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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