OR8H1

Protein-coding gene in the species Homo sapiens
OR8H1
Identifiers
AliasesOR8H1, OR11-180, olfactory receptor family 8 subfamily H member 1
External IDsMGI: 3030933; HomoloGene: 107003; GeneCards: OR8H1; OMA:OR8H1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR8H1
Genomic location for OR8H1
Band11q12.1Start56,288,462 bp[1]
End56,292,254 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for OR8H1
Genomic location for OR8H1
Band2|2 DStart86,785,470 bp[2]
End86,791,037 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • aorta

  • ascending aorta
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • olfactory receptor activity
  • odorant binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • response to stimulus
  • signal transduction
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

219469

258764

Ensembl

ENSG00000262611
ENSG00000181693

ENSMUSG00000075168

UniProt

Q8NGG4

Q8VG37

RefSeq (mRNA)

NM_001005199

NM_146768

RefSeq (protein)

NP_001005199

NP_666979

Location (UCSC)Chr 11: 56.29 – 56.29 MbChr 2: 86.79 – 86.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 8H1 is a protein that in humans is encoded by the OR8H1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c ENSG00000181693 GRCh38: Ensembl release 89: ENSG00000262611, ENSG00000181693 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075168 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR8H1 olfactory receptor, family 8, subfamily H, member 1".

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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