OR5AN1

Protein-coding gene in the species Homo sapiens
OR5AN1
Identifiers
AliasesOR5AN1, OR11-244, olfactory receptor family 5 subfamily AN member 1
External IDsOMIM: 615702; MGI: 3031268; HomoloGene: 45029; GeneCards: OR5AN1; OMA:OR5AN1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR5AN1
Genomic location for OR5AN1
Band11q12.1Start59,358,895 bp[1]
End59,371,714 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for OR5AN1
Genomic location for OR5AN1
Band19|19 AStart12,257,218 bp[2]
End12,262,990 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • odorant binding
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
  • detection of chemical stimulus involved in sensory perception
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

390195

258680

Ensembl

ENSG00000176495

ENSMUSG00000095640

UniProt

Q8NGI8

n/a

RefSeq (mRNA)

NM_001004729

NM_146685

RefSeq (protein)

NP_001004729

n/a

Location (UCSC)Chr 11: 59.36 – 59.37 MbChr 19: 12.26 – 12.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 5AN1 is a protein that in humans is encoded by the OR5AN1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176495 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000095640 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR5AN1 olfactory receptor, family 5, subfamily AN, member 1".
  6. ^ Ahmed, L., et al. (2018). "Molecular Mechanism of Activation of Human Musk Receptors OR5AN1 and OR1A1 by (R)-Muscone and Diverse Other Musk-smelling Compounds". Proc. Natl. Acad. Sci. USA. 115 (17): E3950–E3958. Bibcode:2018PNAS..115E3950A. doi:10.1073/pnas.1713026115. PMC 5924878. PMID 29632183.

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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