OR1S1

Protein-coding gene in the species Homo sapiens
OR1S1
Identifiers
AliasesOR1S1, OR11-232, OST034, olfactory receptor family 1 subfamily S member 1 (gene/pseudogene), olfactory receptor family 1 subfamily S member 1
External IDsMGI: 3031330; HomoloGene: 17458; GeneCards: OR1S1; OMA:OR1S1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR1S1
Genomic location for OR1S1
Band11q12.1Start58,212,720 bp[1]
End58,216,084 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for OR1S1
Genomic location for OR1S1
Band19|19 AStart13,755,242 bp[2]
End13,760,284 bp[2]
Gene ontology
Molecular function
  • transmembrane signaling receptor activity
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • detection of chemical stimulus involved in sensory perception
  • detection of chemical stimulus involved in sensory perception of smell
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

219959

258991

Ensembl

ENSG00000280204

ENSMUSG00000048356

UniProt

Q8NH92

B9EHG2

RefSeq (mRNA)

NM_001004458

NM_146989

RefSeq (protein)

NP_001004458

NP_667200

Location (UCSC)Chr 11: 58.21 – 58.22 MbChr 19: 13.76 – 13.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 1S1 is a protein that in humans is encoded by the OR1S1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000280204 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048356 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR1S1 olfactory receptor, family 1, subfamily S, member 1".

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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