OR1E1

Protein-coding gene in the species Homo sapiens
OR1E1
Identifiers
AliasesOR1E1, HGM071, OR13-66, OR17-2, OR17-32, OR1E5, OR1E6, OR1E8P, OR1E9P, OST547, olfactory receptor family 1 subfamily E member 1
External IDsMGI: 3030231; HomoloGene: 74111; GeneCards: OR1E1; OMA:OR1E1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for OR1E1
Genomic location for OR1E1
Band17p13.3Start3,397,104 bp[1]
End3,398,410 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for OR1E1
Genomic location for OR1E1
Band11|11 B4Start73,851,643 bp[2]
End73,858,638 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • gastrocnemius muscle

  • placenta

  • mammary gland

  • breast

  • lactiferous gland

  • prefrontal cortex

  • temporal lobe

  • tibial nerve

  • sigmoid colon
    n/a
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • transmembrane signaling receptor activity
  • signal transducer activity
  • olfactory receptor activity
Cellular component
  • membrane
  • plasma membrane
  • integral component of membrane
Biological process
  • detection of chemical stimulus involved in sensory perception
  • signal transduction
  • response to stimulus
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8387

258343

Ensembl

ENSG00000180016

ENSMUSG00000057050

UniProt

P30953

Q8VEZ6

RefSeq (mRNA)

NM_003553

NM_146346

RefSeq (protein)

NP_003544

NP_666458

Location (UCSC)Chr 17: 3.4 – 3.4 MbChr 11: 73.85 – 73.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 1E1 is a protein that in humans is encoded by the OR1E1 gene.[5][6][7]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180016 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057050 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H, et al. (Jul 1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum Mol Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088.
  6. ^ Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. Bibcode:1992Natur.355..453P. doi:10.1038/355453a0. PMID 1370859. S2CID 43926.
  7. ^ a b "Entrez Gene: OR1E1 olfactory receptor, family 1, subfamily E, member 1".

Further reading

  • Rouquier S, Taviaux S, Trask BJ, et al. (1998). "Distribution of olfactory receptor genes in the human genome". Nat. Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID 9500546. S2CID 31129045.
  • Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. S2CID 23416814.
  • Rouquier S, Blancher A, Giorgi D (2000). "The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2870–4. Bibcode:2000PNAS...97.2870R. doi:10.1073/pnas.040580197. PMC 16022. PMID 10706615.
  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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