OR1C1

Protein-coding gene in the species Homo sapiens
OR1C1
Identifiers
AliasesOR1C1, HSTPCR27, OR1-42, OR1.5.10, ORL211, TPCR27, olfactory receptor family 1 subfamily C member 1
External IDsHomoloGene: 137247; GeneCards: OR1C1; OMA:OR1C1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for OR1C1
Genomic location for OR1C1
Band1q44Start247,754,846 bp[1]
End247,760,556 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • prosencephalon

  • neocortex

  • tendon

  • brain

  • zone of skin
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26188

n/a

Ensembl

ENSG00000221888

n/a

UniProt

Q15619

n/a

RefSeq (mRNA)

NM_012353

n/a

RefSeq (protein)

NP_036485

n/a

Location (UCSC)Chr 1: 247.75 – 247.76 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Olfactory receptor 1C1 is a protein that in humans is encoded by the OR1C1 gene.[3][4]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000221888 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M (Apr 1997). "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species". Genomics. 39 (3): 239–46. doi:10.1006/geno.1996.4490. PMID 9119360.
  4. ^ a b "Entrez Gene: OR1C1 olfactory receptor, family 1, subfamily C, member 1".

Further reading

  • Fuchs T, Malecova B, Linhart C (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Gregory SG, Barlow KF, McLay KE (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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