OR2T12

Protein-coding gene in the species Homo sapiens
OR2T12
Identifiers
AliasesOR2T12, OR1-57, olfactory receptor family 2 subfamily T member 12
External IDsMGI: 3030148; HomoloGene: 88370; GeneCards: OR2T12; OMA:OR2T12 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for OR2T12
Genomic location for OR2T12
Band1q44Start248,290,139 bp[1]
End248,303,424 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for OR2T12
Genomic location for OR2T12
Band11|11 B1.3Start58,673,778 bp[2]
End58,679,594 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

127064

257917

Ensembl

ENSG00000177201

ENSMUSG00000059504

UniProt

Q8NG77

Q7TRZ7

RefSeq (mRNA)

NM_001004692

NM_001011760

RefSeq (protein)

NP_001004692

NP_001011760

Location (UCSC)Chr 1: 248.29 – 248.3 MbChr 11: 58.67 – 58.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2T12 is a protein that in humans is encoded by the OR2T12 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177201 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059504 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR2T12 olfactory receptor, family 2, subfamily T, member 12". Ncbi.nlm.nih.gov. Retrieved 2013-12-03.

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
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Class II
(tetrapod specific receptors)
Family 1
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