OR4K1

Protein-coding gene in the species Homo sapiens
OR4K1
Identifiers
AliasesOR4K1, OR14-19, olfactory receptor family 4 subfamily K member 1
External IDsMGI: 3030562; HomoloGene: 74224; GeneCards: OR4K1; OMA:OR4K1 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for OR4K1
Genomic location for OR4K1
Band14q11.2Start19,930,917 bp[1]
End19,936,757 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for OR4K1
Genomic location for OR4K1
Band14|14 C1Start50,371,215 bp[2]
End50,380,137 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gallbladder
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transmembrane signaling receptor activity
  • olfactory receptor activity
  • signal transducer activity
  • G protein-coupled receptor activity
Cellular component
  • membrane
  • integral component of membrane
  • plasma membrane
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79544

258039

Ensembl

ENSG00000155249

ENSMUSG00000050030

UniProt

Q8NGD4

Q7TRM6

RefSeq (mRNA)

NM_001004063

NM_001011809

RefSeq (protein)

NP_001004063

NP_001011809

Location (UCSC)Chr 14: 19.93 – 19.94 MbChr 14: 50.37 – 50.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 4K1 is a protein that in humans is encoded by the OR4K1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155249 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050030 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR4K1 olfactory receptor, family 4, subfamily K, member 1".

Further reading

  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13
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