OR2L8

Protein-coding gene in the species Homo sapiens
OR2L8
Identifiers
AliasesOR2L8, olfactory receptor family 2 subfamily L member 8 (gene/pseudogene), olfactory receptor family 2 subfamily L member 8
External IDsMGI: 3030001; HomoloGene: 128185; GeneCards: OR2L8; OMA:OR2L8 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for OR2L8
Genomic location for OR2L8
Band1q44Start247,948,858 bp[1]
End247,949,796 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for OR2L8
Genomic location for OR2L8
Band16|16 A3Start19,328,308 bp[2]
End19,341,016 bp[2]
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
  • molecular function
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

391190

258937

Ensembl

ENSG00000279263

ENSMUSG00000045341

UniProt

Q8NGY9

Q8VGJ5

RefSeq (mRNA)

NM_001001963

NM_146935

RefSeq (protein)

NP_001001963

NP_667146

Location (UCSC)Chr 1: 247.95 – 247.95 MbChr 16: 19.33 – 19.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2L8 is a protein that in humans is encoded by the OR2L8 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000279263 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045341 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR2L8 olfactory receptor, family 2, subfamily L, member 8".

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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