OR2W3

Protein-coding gene in the species Homo sapiens
OR2W3
Identifiers
AliasesOR2W3, OR2W3P, OR2W8P, OST718, olfactory receptor family 2 subfamily W member 3
External IDsOMIM: 616729; MGI: 3030156; HomoloGene: 19876; GeneCards: OR2W3; OMA:OR2W3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for OR2W3
Genomic location for OR2W3
Band1q44Start247,895,587 bp[1]
End247,896,531 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for OR2W3
Genomic location for OR2W3
Band11|11 B1.3Start58,549,608 bp[2]
End58,560,354 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • blood

  • monocyte

  • trabecular bone

  • bone marrow

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • prefrontal cortex

  • tibial nerve

  • bone marrow cells
Top expressed in
  • bone marrow
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • olfactory receptor activity
Cellular component
  • membrane
  • plasma membrane
  • integral component of membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

343171

404346

Ensembl

ENSG00000238243

ENSMUSG00000063549

UniProt

Q7Z3T1

Q5NCC8

RefSeq (mRNA)

NM_001001957

NM_207693

RefSeq (protein)

NP_001001957

NP_997576

Location (UCSC)Chr 1: 247.9 – 247.9 MbChr 11: 58.55 – 58.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2W3 is a protein that in humans is encoded by the OR2W3 gene.[5][6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000238243 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063549 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Malnic B, Godfrey PA, Buck LB (Feb 2004). "The human olfactory receptor gene family". Proc Natl Acad Sci U S A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  6. ^ a b "Entrez Gene: OR2W3 olfactory receptor, family 2, subfamily W, member 3".

Further reading

  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
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Family 13
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