OR2J3

Protein-coding gene in the species Homo sapiens
OR2J3
Identifiers
AliasesOR2J3, 6M1-3, C3HEXS, HS6M1-3, OR6-16, OR6-6, OR6.3.6, ORL671, olfactory receptor family 2 subfamily J member 3
External IDsOMIM: 615016; MGI: 2177520; HomoloGene: 128270; GeneCards: OR2J3; OMA:OR2J3 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for OR2J3
Genomic location for OR2J3
Band6p22.1Start29,108,058 bp[1]
End29,114,770 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for OR2J3
Genomic location for OR2J3
Band17|17 B1Start38,614,418 bp[2]
End38,618,461 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • sural nerve

  • left testis

  • right testis
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

442186

258481

Ensembl

ENSG00000204701

ENSMUSG00000054940

UniProt

O76001

Q8VFC2

RefSeq (mRNA)

NM_001005216

NM_146488

RefSeq (protein)

NP_001005216

NP_666699

Location (UCSC)Chr 6: 29.11 – 29.11 MbChr 17: 38.61 – 38.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2J3 is a protein that in humans is encoded by the OR2J3 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Genetic variation

A pair of two single-nucleotide polymorphisms, both in the OR2J3 gene, strongly reduce sensitivity to the odorant cis-3-hexen-1-ol, which has a "cut grass" smell.[6]

Ligands

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204701 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054940 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR2J3 olfactory receptor, family 2, subfamily J, member 3".
  6. ^ a b McRae JF, Mainland JD, Jaeger SR, Adipietro KA, Matsunami H, Newcomb RD (September 2012). "Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol". Chemical Senses. 37 (7): 585–93. doi:10.1093/chemse/bjs049. PMC 3408771. PMID 22714804.
  7. ^ Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC 3990440. PMID 24316890.

Further reading

  • Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, et al. (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
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Class II
(tetrapod specific receptors)
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