OR1B1

Protein-coding gene in the species Homo sapiens
OR1B1
Identifiers
AliasesOR1B1, OR9-26, OR9-B, olfactory receptor family 1 subfamily B member 1 (gene/pseudogene), olfactory receptor family 1 subfamily B member 1
External IDsMGI: 3030196; HomoloGene: 17479; GeneCards: OR1B1; OMA:OR1B1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for OR1B1
Genomic location for OR1B1
Band9q33.2Start122,628,579 bp[1]
End122,629,573 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for OR1B1
Genomic location for OR1B1
Band2|2 BStart36,991,718 bp[2]
End37,007,922 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • placenta

  • endometrium

  • cervix

  • lymph node

  • right lung

  • gallbladder

  • superior frontal gyrus

  • canal of the cervix
Top expressed in
  • spermatid

  • testicle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • transmembrane signaling receptor activity
  • olfactory receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • detection of chemical stimulus involved in sensory perception
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

347169

259053

Ensembl

ENSG00000280094

ENSMUSG00000075377

UniProt

Q8NGR6

Q8VGV7

RefSeq (mRNA)

NM_001004450

NM_147051

RefSeq (protein)

NP_001004450

NP_667262

Location (UCSC)Chr 9: 122.63 – 122.63 MbChr 2: 36.99 – 37.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 1B1 is a protein that in humans is encoded by the OR1B1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

As of 2024, OR1B1 was an orphan receptor, meaning that no odorants have been identified which bind to it.[6][7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000280094 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075377 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR1B1 olfactory receptor, family 1, subfamily B, member 1".
  6. ^ de March CA, Ryu S, Sicard G, Moon C, Golebiowski J (September 2015). "Structure–odour relationships reviewed in the postgenomic era". Flavour and Fragrance Journal. 30 (5): 342–361. doi:10.1002/ffj.3249.
  7. ^ "OR1B1". M2OR. ChemSenSim lab, Université Côte d’Azur, Institut de Chimie de Nice. 2024-03-23. Retrieved 2024-07-04.

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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