OR5T2

Protein-coding gene in the species Homo sapiens
OR5T2
Identifiers
AliasesOR5T2, OR11-177, olfactory receptor family 5 subfamily T member 2
External IDsMGI: 3030920; HomoloGene: 73975; GeneCards: OR5T2; OMA:OR5T2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR5T2
Genomic location for OR5T2
Band11q12.1Start56,231,282 bp[1]
End56,234,255 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for OR5T2
Genomic location for OR5T2
Band2|2 DStart86,506,562 bp[2]
End86,510,436 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endometrium
    n/a
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
  • neurotransmitter receptor activity
  • G protein-coupled serotonin receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • integral component of plasma membrane
  • dendrite
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • signal transduction
  • response to stimulus
  • G protein-coupled serotonin receptor signaling pathway
  • G protein-coupled receptor signaling pathway
  • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • chemical synaptic transmission
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

219464

258585

Ensembl

ENSG00000181718
ENSG00000262851

ENSMUSG00000075175

UniProt

Q8NGG2

Q8VFL9

RefSeq (mRNA)

NM_001004746

NM_146592

RefSeq (protein)

NP_001004746

NP_666803

Location (UCSC)Chr 11: 56.23 – 56.23 MbChr 2: 86.51 – 86.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 5T2 is a protein that in humans is encoded by the OR5T2 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c ENSG00000262851 GRCh38: Ensembl release 89: ENSG00000181718, ENSG00000262851 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075175 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR5T2 olfactory receptor, family 5, subfamily T, member 2".

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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