OR13A1

Protein-coding gene in the species Homo sapiens
OR13A1
Identifiers
AliasesOR13A1, olfactory receptor family 13 subfamily A member 1
External IDsMGI: 3030045; HomoloGene: 17434; GeneCards: OR13A1; OMA:OR13A1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for OR13A1
Genomic location for OR13A1
Band10q11.21Start45,302,298 bp[1]
End45,315,608 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for OR13A1
Genomic location for OR13A1
Band6|6 E3Start116,466,052 bp[2]
End116,475,182 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • lymph node

  • spleen

  • granulocyte

  • mucosa of esophagus

  • blood

  • urinary bladder

  • mucosa of transverse colon

  • cerebellar cortex

  • cerebellar hemisphere
Top expressed in
  • respiratory epithelium

  • nasal epithelium

  • olfactory epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • odorant binding
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79290

258914

Ensembl

ENSG00000277495
ENSG00000256574

ENSMUSG00000053391

UniProt

Q8NGR1

Q8VGH2

RefSeq (mRNA)

NM_001004297

NM_146912

RefSeq (protein)

NP_001004297

NP_667123

Location (UCSC)Chr 10: 45.3 – 45.32 MbChr 6: 116.47 – 116.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 13A1 is a protein that in humans is encoded by the OR13A1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c ENSG00000256574 GRCh38: Ensembl release 89: ENSG00000277495, ENSG00000256574 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053391 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR13A1 olfactory receptor, family 13, subfamily A, member 1".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–2589. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–381. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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