OR2T1

Protein-coding gene in the species Homo sapiens
OR2T1
Identifiers
AliasesOR2T1, OR1-25, olfactory receptor family 2 subfamily T member 1
External IDsMGI: 109304; HomoloGene: 74028; GeneCards: OR2T1; OMA:OR2T1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for OR2T1
Genomic location for OR2T1
Band1q44Start248,403,048 bp[1]
End248,408,020 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for OR2T1
Genomic location for OR2T1
Band14|14 A1Start8,137,972 bp[2]
End8,146,935 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • brain

  • prefrontal cortex

  • cerebral cortex

  • multicellular organism
Top expressed in
  • hypothalamus

  • genital tubercle

  • spermatid
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26696

18330

Ensembl

ENSG00000275244
ENSG00000273508
ENSG00000175143

ENSMUSG00000072707

UniProt

O43869

n/a

RefSeq (mRNA)

NM_030904

NM_147027

RefSeq (protein)

NP_112166

n/a

Location (UCSC)Chr 1: 248.4 – 248.41 MbChr 14: 8.14 – 8.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2T1 is a protein that in humans is encoded by the OR2T1 gene.[5][6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

See also

References

  1. ^ a b c ENSG00000273508, ENSG00000175143 GRCh38: Ensembl release 89: ENSG00000275244, ENSG00000273508, ENSG00000175143 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072707 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (Mar 1998). "Distribution of olfactory receptor genes in the human genome". Nat Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID 9500546. S2CID 31129045.
  6. ^ a b "Entrez Gene: OR2T1 olfactory receptor, family 2, subfamily T, member 1".

Further reading

  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13
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