OR2C1

Protein-coding gene in the species Homo sapiens
OR2C1
Identifiers
AliasesOR2C1, OLFmf3, OR2C2P, olfactory receptor family 2 subfamily C member 1
External IDsMGI: 106182; HomoloGene: 7459; GeneCards: OR2C1; OMA:OR2C1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for OR2C1
Genomic location for OR2C1
Band16p13.3Start3,355,889 bp[1]
End3,357,306 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for OR2C1
Genomic location for OR2C1
Band16|16 A1Start3,648,742 bp[2]
End3,662,611 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibialis anterior muscle

  • mucosa of ileum

  • deltoid muscle

  • ventricular zone

  • uterine tube

  • right uterine tube

  • lymph node

  • islet of Langerhans

  • primary visual cortex

  • spinal cord
Top expressed in
  • Jacobson's organ

  • respiratory epithelium

  • nasal epithelium

  • olfactory epithelium

  • gastrula

  • CA3 field

  • skin of abdomen
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • olfactory receptor activity
  • odorant binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • cell cortex
Biological process
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • sensory perception of smell
  • G protein-coupled receptor signaling pathway
  • detection of chemical stimulus involved in sensory perception
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4993

18312

Ensembl

ENSG00000168158

ENSMUSG00000059043

UniProt

O95371

P23275

RefSeq (mRNA)

NM_012368

NM_008762

RefSeq (protein)

NP_036500

NP_032788

Location (UCSC)Chr 16: 3.36 – 3.36 MbChr 16: 3.65 – 3.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2C1 is a protein that in humans is encoded by the OR2C1 gene.[5][6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

Ligands

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168158 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059043 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Centola M, Chen X, Sood R, Deng Z, Aksentijevich I, Blake T, Ricke DO, Chen X, Wood G, Zaks N, Richards N, Krizman D, Mansfield E, Apostolou S, Liu J, Shafran N, Vedula A, Hamon M, Cercek A, Kahan T, Gumucio D, Callen DF, Richards RI, Moyzis RK, Doggett NA, Collins FS, Liu PP, Fischel-Ghodsian N, Kastner DL (Jan 1999). "Construction of an ~700-kb Transcript Map Around the Familial Mediterranean Fever Locus on Human Chromosome 16p13.3". Genome Res. 8 (11): 1172–91. doi:10.1101/gr.8.11.1172. PMC 310791. PMID 9847080.
  6. ^ a b "Entrez Gene: OR2C1 olfactory receptor, family 2, subfamily C, member 1".
  7. ^ a b Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class II
(tetrapod specific receptors)
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