OR8D2

Protein-coding gene in the species Homo sapiens
OR8D2
Identifiers
AliasesOR8D2, JCG2, olfactory receptor family 8 subfamily D member 2 (gene/pseudogene), olfactory receptor family 8 subfamily D member 2
External IDsMGI: 3030758; HomoloGene: 128215; GeneCards: OR8D2; OMA:OR8D2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR8D2
Genomic location for OR8D2
Band11q24.2Start124,319,262 bp[1]
End124,320,197 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for OR8D2
Genomic location for OR8D2
Band9|9 A5.1Start38,755,745 bp[2]
End38,762,791 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • odorant binding
  • signal transducer activity
  • olfactory receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

283160

404322

Ensembl

ENSG00000279116

ENSMUSG00000062103

UniProt

Q9GZM6

Q7TRB8

RefSeq (mRNA)

NM_001002918

NM_207560

RefSeq (protein)

NP_001002918

NP_997443

Location (UCSC)Chr 11: 124.32 – 124.32 MbChr 9: 38.76 – 38.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 8D2 is a protein that in humans is encoded by the OR8D2 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000279116 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062103 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR8D2 olfactory receptor, family 8, subfamily D, member 2".

Further reading

  • Gaudin JC, Breuils L, Haertlé T (2002). "New GPCRs from a human lingual cDNA library". Chem. Senses. 26 (9): 1157–66. doi:10.1093/chemse/26.9.1157. PMID 11705801.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
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Family 56
Class II
(tetrapod specific receptors)
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