OR7A17

Protein-coding gene in the species Homo sapiens
OR7A17
Identifiers
AliasesOR7A17, BC85395_4, HTPCRX19, olfactory receptor family 7 subfamily A member 17
External IDsMGI: 109316; HomoloGene: 137402; GeneCards: OR7A17; OMA:OR7A17 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for OR7A17
Genomic location for OR7A17
Band19p13.12Start14,878,203 bp[1]
End14,886,132 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for OR7A17
Genomic location for OR7A17
Band16|16 A3Start16,490,092 bp[2]
End16,494,269 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve
Top expressed in
  • respiratory epithelium

  • nasal epithelium

  • olfactory epithelium

  • embryo

  • testicle

  • spermatid
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • signal transduction
  • response to stimulus
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26333

18316

Ensembl

ENSG00000185385

ENSMUSG00000048101

UniProt

O14581

Q9JHB2

RefSeq (mRNA)

NM_030901

NM_146335

RefSeq (protein)

NP_112163

NP_666447

Location (UCSC)Chr 19: 14.88 – 14.89 MbChr 16: 16.49 – 16.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 7A17 is a protein that in humans is encoded by the OR7A17 gene.[5][6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185385 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048101 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. Bibcode:1992Natur.355..453P. doi:10.1038/355453a0. PMID 1370859. S2CID 43926.
  6. ^ a b "Entrez Gene: OR7A17 olfactory receptor, family 7, subfamily A, member 17".

Further reading

  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
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Family 8
Family 9
Family 10
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Family 13


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