OR5T3

Protein-coding gene in the species Homo sapiens
OR5T3
Identifiers
AliasesOR5T3, OR11-178, OR5T3Q, olfactory receptor family 5 subfamily T member 3
External IDsMGI: 3030927; HomoloGene: 133610; GeneCards: OR5T3; OMA:OR5T3 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR5T3
Genomic location for OR5T3
Band11q12.1Start56,252,254 bp[1]
End56,253,222 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for OR5T3
Genomic location for OR5T3
Band2|2 DStart86,612,823 bp[2]
End86,617,960 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
  • neurotransmitter receptor activity
  • G protein-coupled serotonin receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • integral component of plasma membrane
  • dendrite
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • signal transduction
  • response to stimulus
  • G protein-coupled serotonin receptor signaling pathway
  • G protein-coupled receptor signaling pathway
  • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • chemical synaptic transmission
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

390154

258363

Ensembl

ENSG00000172489
ENSG00000261897

ENSMUSG00000047969

UniProt

Q8NGG3

Q8VF14

RefSeq (mRNA)

NM_001004747

NM_146366
NM_001368206

RefSeq (protein)

NP_001004747

NP_666478
NP_001355135

Location (UCSC)Chr 11: 56.25 – 56.25 MbChr 2: 86.61 – 86.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 5T3 is a protein that in humans is encoded by the OR5T3 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c ENSG00000261897 GRCh38: Ensembl release 89: ENSG00000172489, ENSG00000261897 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047969 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR5T3 olfactory receptor, family 5, subfamily T, member 3".

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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