OR12D2

Protein-coding gene in the species Homo sapiens
OR12D2
Identifiers
AliasesOR12D2, DJ994E9.8, HS6M1-20, olfactory receptor family 12 subfamily D member 2 (gene/pseudogene), olfactory receptor family 12 subfamily D member 2
External IDsMGI: 2177484; HomoloGene: 133728; GeneCards: OR12D2; OMA:OR12D2 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for OR12D2
Genomic location for OR12D2
Band6p22.1Start29,395,631 bp[1]
End29,398,008 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for OR12D2
Genomic location for OR12D2
Band17|17 B1Start37,608,447 bp[2]
End37,615,204 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • hypothalamus

  • hippocampus proper

  • caudate nucleus

  • temporal lobe

  • amygdala

  • C1 segment

  • Brodmann area 9

  • nucleus accumbens
Top expressed in
  • spleen
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • transmembrane signaling receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • detection of chemical stimulus involved in sensory perception
  • signal transduction
  • response to stimulus
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26529

258831

Ensembl

ENSG00000280236

ENSMUSG00000092077

UniProt

P58182

Q920Z0

RefSeq (mRNA)

NM_013936

NM_146834

RefSeq (protein)

NP_039224

NP_667045

Location (UCSC)Chr 6: 29.4 – 29.4 MbChr 17: 37.61 – 37.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor, family 12, subfamily D, member 2, also known as OR12D2, is a protein which in humans is encoded by the OR12D2 gene.[5]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000280236 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000092077 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR12D2 olfactory receptor, family 12, subfamily D, member 2".

Further reading

  • Younger RM, Amadou C, Bethel G, et al. (2001). "Characterization of clustered MHC-linked olfactory receptor genes in human and mouse". Genome Res. 11 (4): 519–30. doi:10.1101/gr.gr-1603r. PMC 311051. PMID 11282967.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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